I. Polypeptide-based drug delivery systems for therapeutics
1. Dong Woo Lim, Jae Sang Lee, Min Jung Kang, “Dynamic Nanocarriers of the Calmodulin-elastin Diblock Polypeptides with Multi-stimuli Responsiveness for Smart Drug Delivery Systems and Methods for Preparing thereof”,
– Korea patent, 10-2028931 (2019.09.30), 10-2017-0037344, (2017.03.24), 10-2016-0035330 (2016.03.24)
2. Dong Woo Lim, Min Jung Kang, Jae Sang Lee, “Cell penetrating peptide-elastin multi-block polypepetides and their self-assembled nanostructures for enhanced intracellular delivery of multiple drugs”
– Korea patent, 10-1837537(2018.03.06), 10-2016-0126477 (2016.09.30), 10-2015-0139205 (2015.10.02)
3. Dong Woo Lim, Min Jung Kang, Jae Sang Lee, Sae-Gwang Park, “Vascular endothelial growth factor receptor targeting peptide-elastin fusion polypeptides and their self-assembled nanostructures, methods for preparing thereof and their nanomedicine applications for anti-angiogenesis”
– PCT/KR2016/011757 (2016.10.19), US patent, (1) US 10,662,236 B2 (2020.05.26), (2) US 11,518,798 B2 (2022.12.06), EU patent, EP 3 424 948 B1 (2021.07.28), Japan patent, 6600405 (2019.10.11), Korea patent, 10-1975743 (2019.04.30)
4. Dong Woo Lim and Min Jung Kang, “Fusion polypeptides for inhibiting angiogenesis, fusion protein nanocages having multivalent peptides for inhibiting angiogenesis, and theranostic use thereof”,
– PCT/KR2020/005176 (2020.04.17), US patent pending US 17/604,414 (2021.10.16), Korea patent, 10-2413729 (2022.06.23), 10-2020-0046920 (2020.04.17), 10-2019-0045484 (2019.04.18)
5. Dong Woo Lim, Min Jung Kang, “Multi-stimuli responsive block copolypeptide-based drug delivery systems”
– Korea patent, 10-2412681 (2022.06.21), 10-2020-0046902 (2020.04.17), 10-2019-0045526 (2019.04.18)
6. Dong Woo Lim, Min Jung Kang, Jae Sang Lee, Aamna Basheer, Jae Hee Lee, Sae-Gwang Park, Kug-Hwan Roh, “Fusion polypeptides in which pigment epithelial-derived factor peptide and elastin based polypeptide are combined and phamaceutical compositions for inhibiting angiogenesis comprising thereof”
– Korea patent, 10-2479599 (2022.12.16), 10-2020-0047014 (2020.04.17), 10-2019-0045584 (2019.04.18)
7. Dong Woo Lim, Aamna Basheer, Jae Sang Lee, Min Jung Kang, “Self-assembled nanostructures of elastin and resilin-based block copolypeptides with stimuli responsiveness and resilience for drug delivery system, tissue engineering, and regenerative medicine and methods of preparing thereof”
– PCT/KR2017/003113 (2017.03.23), US patent pending, US 16/087,774 (2017.03.23), Korea patent, 10-1952835 (2019.02.21), 10-2017-0036888 (2017.03.23), 10-2016-0034372 (2016.03.23)
8. Dong Woo Lim, Aamna Basheer, Jae Sang Lee, Min Jung Kang, “Elastin Fusion Proteins with Coiled-coil forming peptides, Their Stimuli-triggered Self-assembly, Methods of Preparation and Biomedical use Thereof”,
– Korea patent, 10-2039460 (2019.10.28), 10-2017-0125900 (2017.09.28), 10-2016-0126510 (2016.09.30)
9. Sae-Gwang Park, Dong Woo Lim, Hana Jung, Ilyoung Han, Sungjae Park, Kijung Ahn, “Interferon beta-elastin recombinant protein and its production method”,
– Korea patent, 10-1955366 (2019.02.28), 10-2017-0069109 (2017.06.02)
10. Sae Gwang Park, Kug-Hwan Roh, Dong Woo Lim, Hana Jung, Hyun Ung Kim, Min Jung Kang, “Recombinant proteins for antiangiogenesis and their medical use”,
– Korean patent, 10-2020-0027337 (2020.03.04)
11. Dong Woo Lim, Min Jung Kang, Eun Young Hwang, “Protein- Polymer Hybrid Nanostructures prepared by Polymerization- induced Self- Assembly for Anti- angiogenesis and their pharmaceutical compositions”
– Korean patent, 10-2021-0111306 (2021.08.24), 10-2020-0106678 (2020.08.25)
12. Dong Woo Lim, Shahzaib Shahid, Min Jung Kang, “Multivalent Vesicles of Stimuli-Responsive Elastin- and Resilin-Based Diblock Copolypeptides with an Anti-angiogenic Peptide”, “
– Korean patent, 10-2023-0043565 (2023.04.03)
13. Dong Woo Lim, Shahzaib Shahid, Jae Sang Lee, “Anisotropic Nanofibers of Coiled-coil Peptide-based Triblock Copolypeptides for Decoupled Drug Release”
– Korean patent, 10-2023-0043557 (2023.04.03)
II. Injectable polypeptide hydrogels for regenerative medicine and tissue engineering
1. Dong Woo Lim, Jae Sang Lee, Min Jung Kang, “Polypeptides with phase transition, triblock polypeptides of the polypeptide-calmodulin-polypeptide with multi-stimuli responsiveness, hydrogel of the triblock polypeptides, and its uses”
– PCT/KR2016/003658 (2016.04.07), US patent, 11,059,870 (2021.07.13), Korea patent, 10-1936470 (2019.01.10), 10-2017-0037344, (2017.03.24), 10-2016-0035330 (2016.03.24)
2. Dong Woo Lim, Jae Hee Lee, Jae Sang Lee, “Stimuli-responsive and surface adhesive block copolypeptides of elastin-based polypeptides (EBPs) and Mussel foot proteins (MFPs), and their self-assembled structures”
– PCT/KR2018/004029 (2018.04.05), US patent pending US 16/500,177 (2019.10.02), Korea patent, 10-2070124 (2020.01.20), 10-2018-0039787 (2018.04.05), 10-2017-0044225 (2017.04.05)
3. Dong Woo Lim, Jae Hee Lee, “Sticky elastin-based multiblock copolypeptides with stimuli- responsiveness and surface adhesion properties, their self- assembled nanostructures and injectable hydrogels as bio- adhesives for biomedical applications”
– Korean patent, 10-2021-0111308 (2021.08.24), 10-2020-0105908 (2020.08.24)
4. Dong Woo Lim, Jae Hee Lee, Aamna Basheer, “Adhesive elastin and suckerin-based multiblock copolypeptides with stimuli responsiveness and surface adhesion, self-assembled structure thereof, and application of injectable hydrogel as bioadhesive”
– PCT/KR2021/011329 (2021.08.25), US patent pending US 17/998,864 (2022.11.15), Korean patent, 10-2021-0111312 (2021.08.24), 10-2020-0106701 (2020.08.25)
III. Anisotropic polymer biomaterials for nanomedicine
1. Dong Woo Lim, Chan Woo Jung, Ghulam Jalani, and Jae Sang Lee, “Anisotropic Nanofiber Structures for Stimuli―responsive Mechanical Actuation and Method for Preparing Thereof”
– Korea patent, 10-1408059 (2014.06.10)
2. Dong Woo Lim, Jinho Hyun, and Jae Sang Lee, “Anisotropic Polypeptide Nanostructures with Environmentally Responsiveness by Spontaneous Structure Transformation and Method for Preparing thereof”,
– Korea patent, 10-1518121 (2015.04.29)
3. Dong Woo Lim, and Ahmed Ali, “Electric Field-responsive Anisotropic Nano-architectures for Smart Drug Delivery Systems and the Method Thereof”
– Korea patent, 10-2008251 (2019.08.01), 10-2017-0134022 (2017.10.16), 10-2016-0134190 (2016.10.17)
4. Dong Woo Lim and Agnes Anania Triavika Saha, “Self-assembled polyelectrolyte complex structures of multi-stimuli responsive ABC-type triblock copolymers and uses thereof”
– Korea patent, 10-1893158, (2018.08.23), 10-2017-0044235 (2017.04.05), 10-2016-0042034 (2016.04.06)
5. Dong Woo Lim and Agnes Anania Triavika Saha, “Self-assembled polyelectrolyte complex micelles and hydrogels of reducible ABA-type triblock copolymers with multi-stimuli responsiveness and uses thereof”,
– Korea patent, 10-1912845 (2018.10.23), 10-2017-0035817 (2017.03.22), 10-2016-0033736 (2016.03.22)
6. Dong Woo Lim, Hyunki Kang and Eun Young Hwang, “Biodegradable anisotropic nanoparticles based on stereocomplexes between stereo-isomers for controlled release of multiple drugs and methods of preparing thereof”
– Korea patent, 10-1949013 (2019.02.11), 10-2017-0036128 (2017.03.22), 10-2016-0034034 (2016.03.22)
7. Dong Woo Lim and Eun Young Hwang, “Oppositely charged anisotropic nanoparticles with stimuli-responsiveness and their colloidal self-assembled nanostructures”
– Korea patent, 10-1835961 (2018.02.28), 10-2016-0035706 (2016.03.25), 10-2015-0045167 (2015.03.31)
8. Dong Woo Lim and Eun Young Hwang, “Oppositely Charged Anisotropic Nanoparticles with Stimuli-responsiveness for advanced drug delivery”
– Korea patent, 10-1952836 (2019.02.21), 10-2017-0033927 (2017.03.17), 10-2016-0033389 (2016.03.21)
9. Dong Woo Lim and Eun Young Hwang, “Amphiphilic norbornene-based double block copolymers and their molecular brushes with stimuli-responsiveness, their hierarchically self-assembled nanostructures, and their preparation method and use thereof”
– Korea patent, 10-2267670 (2021.06.08), 10-2020-0046685 (2020.04.17), 10-2019-0045446 (2019.04.18)
Organic-inorganic composite nanostructures for SERS-based biosensing and bioimaging
1. Dong Woo Lim and Eun Young Hwang, “Bimetallic nanoparticles with stimuli-responsiveness, process for producing the same, and use thereof”
– Registered US patent, US 11,427,602 B2 (2022.08.30), US patent pending US 16/441,362(2019.06.14), Korea patent, 10-2221139 (2021.02.22), 10-2019 0070155(2019.06.13), 10-2018-0068665(2018.06.15)
2. Dong Woo Lim and Eun Young Hwang, “Electric stimulus-responsive, bimetal-conducting polymer-based Janus composite nanostructures, their self-assembled superparticular structures, synthesis, and their biomedical and industrial applications”
– PCT/KR2017/008620 (2017.08.09), US patent pending, US 16/324,278 (2017.09.08), Korea patent, (1) 10-1986537 (2019.05.31), 10-2017-0100356 (2017.08.08), 10-2016-0101255 (2016.08.09), (2) 10-1986535 (2019.05.31), 10-2017-0100357 (2017.08.08), (3) 10-1986531 (2019.05.31), 10-2017-0100358 (2017.08.08), (4) 10-1986545 (2019.05.31), 10-2017-0100359 (2017.08.08)
3. Dong Woo Lim and Eun Young Hwang, “Core @ shell bimetallic nanoparticles with stimuli-responsiveness, process for producing the same, and use thereof”,
– Korea patent, 10-2221138 (2021.02.22), 10-2019-0070154 (2019.06.13), 10-2018-0068665 (2018.06.15)
4. Dong Woo Lim, Ahmed Ali, and Jae Hee Lee, “Anisotropic acorn-type bimetal nanoparticles, their directionally clustered nanostructures, preparation and Surface Enhanced Raman Scattering (SERS)-based biosensing applications”
– Korea patent, 10-2164579 (2020.10.05), 10-2018-0114918 (2018.09.27), 10-2017-0122732 (2017.09.22)
5. Dong Woo Lim and Eun Young Hwang, Ahmed Ali, “Plasmonic Core-satellite Nanostructures with Stimuli-responsiveness for Surface Enhanced Raman Scattering Applications and the Method Thereof”
– Korea patent, 10-2153950 (2020.09.03), 10-2018-0112914 (2018.09.20), 10-2017-0122729 (2017.09.22)
6. Dong Woo Lim and Eun Young Hwang, Ahmed Ali, Jae Hee Lee, “Directionally Clustered Nanostructures of Compartmentalized Bimetal Nanorods as Surface Enhanced Raman Scattering (SERS) Nanotags for Biosensing and the Methods Thereof”
– Korea patent, 10-2153949 (2020.09.03), 10-2018-0112927 (2018.09.20), 10-2017-0122730 (2017.09.22)
7. Dong Woo Lim, Jae Hee Lee, and Ahmed Ali, “Controlled Nanoclusters of Anisotropic Bimetal Nanostars for Surface-enhanced Raman Scattering-based Biosensing and the Method Thereof “
– Korea patent, 10-2153948 (2020.09.03), 10-2018-0112937 (2018.09.20), 10-2017-0122733 (2017.09.22)
8. Dong Woo Lim, Ahmed Ali, and Jae Hee Lee, “Anisotropic bimetal nanowires, bimetal nanowire-embedded polymer nanofibers, SERS substrates with the anisotropic bimetal nanowires, method thereof and its uses”
– Korea patent, 10-2081391 (2020.02.19), 10-2018-0114917 (2018.09.27), 10-2017-0122731 (2017.09.22)
9. Dong Woo Lim and Eun Young Hwang, “Directional Assembly of Gold Nanorods and their Anisotropic Bimetal Nanorod Cluster-Polymer Hybrid Nanostructures for Biophotonics”,
– Korea patent, 10-1986545 (2019.05.31), 10-2017-0100359 (2017.08.08)
10. Dong Woo Lim and Eun Young Hwang, “Anisotropic Nanostructures with Bimetallic Nanocluster and Conducting Polymer Compartment for Photonics-based Biosensing”
– Korea patent, 10-1986531 (2019.05.31), 10-2017-0100358 (2017.08.08)
11. Dong Woo Lim and Eun Young Hwang, “Ligand-mediated Growth of Bimetallic Core-satellite Nanostructures with Anisotropic Polymer Shell for Biophotonics”
– Korea patent, 10-1986535 (2019.05.31), 10-2017-0100357 (2017.08.08)
12. Dong Woo Lim and Eun Young Hwang, “Controlled Self-assembly of Anisotropic Bimetal-Polymer Hybrid Nanostructures for Surface Enhanced Raman Scattering-based Biosensing”,
– Korea patent, 10-1986537 (2019.05.31), 10-2017-0100356 (2017.08.08)
13. Dong Woo Lim, Ahmed Ali, Jaebum Choo, and Hyunki Kang, “Stimuli-responsive Graphene Oxide-based Polymer Brush and Metallic Nanoparticle Clusters as Inorganic-organic Composite Nanoprobes for Surface Enhanced Raman Scattering-based Biosensing and/or Bioimaging, and the Method Thereof”
– Korea patent, 10-1956262 (2019.03.04), 10-2017-0078001 (2017. 06.20), 10-2016-0076534 (2016.06.20)
14. Dong Woo Lim, Jaebum Choo, Hong Deok Jang, and Eun Young Hwang, “Synthesis of Surface Enhanced Raman Scattering and Fluorescence-based Organic-Inorganic Nanocomposites as Dual Nanoprobes and Their Multiplexed Detection of Biomolecules and Pathogens”
– Korea patent, 10-1839849 (2018.03.13), 10-2015-0046945 (2015.04.02)
15. Dong Woo Lim, Jaebum Choo, Ahmed Ali, “Method of Preparing PEGylated Nanoscale Graphene Mediated Metallic Nanoparticle Clusters for Surface Enhanced Raman Scattering (SERS) Nanoprobes for Biosensing and/or Bioimaging”
– Korea patent, 10-1832818 (2018.02.21), 10-2016-0158589 (2016.11.25), 10-2015-0166313 (2015.11.26),
16. Dong Woo Lim, Jaebum Choo, Ahmed Ali, Hong Deok Jang and Chan Woo Jung, “Graphene Oxide Induced Metallic Nanoparticle Clustering for Surface Enhanced Raman Scattering-based Biosensing and/or Bioimaging”,
– Korea patent, 10-2015-0025631 (2015.02.24), Korea patent, 10-1654461 (2016.08.30)
17. Dong Woo Lim, Jaebum Choo, Ghulam Jalani, Chan Woo Jung, and Hong Deok Jang, “Analysis Methods of Inorganic-organic Nanofiber Composite Substrates for Fast and Sensitive Trace Analysis Based on Surface Enhanced Raman Scattering”
– Korea patent, 10-1598757 (2016.02.23), 10-2015-0083716 (2015.06.12)
18. Dong Woo Lim, Jaebum Choo, Ghulam Jalani, Chan Woo Jung, and Hong Deok Jang, “Methods of Preparing Inorganic-organic Nanofiber Composite Substrates for Fast and Sensitive Trace Analysis Based on Surface Enhanced Raman Scattering”
– Korea patent, 10-1538218 (2015.07.14)
19. Dong Woo Lim, Jaebum Choo, Chan Woo Jung, Ghulam Jalani, and Juhui Ko, “Methods of Preparing Biosensor for Multiplexing Detection System by Using Anisotropic Biohybrid Microparticles and Their Applications”
– Korean patent, 10-1514321 (2015.04.16)
20. Dong Woo Lim, Jaebum Choo, Hong Deok Jang, and Chan Woo Jung, “Stimuli-responsive Surface Enhanced Raman Scattering Substrates with High Sensitivity for Trace Analysis and the Method Thereof”
– Korea patent, 10-1494776 (2015.02.12)
21. Dong Woo Lim, Jaebum Choo, Ghulam Jalani, Sangyeop Lee, and Chan Woo Jung, “Method of Preparing a Biohybrid Metal Nanoprobe for Image Measurement of Surface-Enhanced Raman Scattering”
– Korea patent, 10-1364245 (2014. 02. 10)
* Duke University, Department of Biomedical Engineering (2002 – 2008)
– Lori A. Setton, Ashutosh Chilkoti, Helawe Betre, Kimberly T. Carlson, Melissa McHale, Dong Woo Lim and Dana L. Nettles, “In-situ Crosslinkable Elastin-like Polypeptides for Defect Filling in Cartilaginous Tissue Repair”
– WO 2006078629A2, 2006 (2006.07.27)
* Amore-Pacific R&D Center (2000 – 2002)
– Jung Hwa Yang, Ham Yong Park, Dong Woo Lim, Jung Ju Kim, “Cyclosporin-containing Sustained Release Pharmaceuticals”, PCT, WO 2003063841A1, 2003 (2003.08.07)